Abstract

Objective To study the relation between nodular goiter and thyroid cancer. Methods Immunohistochemical method was used to detect expression of p27 protein in 58 cases of nodular goiter, 15 cases of nodular goiter with hyperplastic nodule, 44 cases of thyroid cancer and 20 cases of normal thyroid tissue. Results The positive expression rate of p27 protein was 60.5% in normal thyroid tissue, 38.6% in nodular goiter, 34.1% in thyroid cancer and 0 in nodular goiter with hyperplastic nodule. The positive expression rate of p27 protein in both nodular goiter and thyroid cancer was significantly higher than this in nodular goiter with hyperplastic nodule (P<0.01). Conclusions Nodular goiter with hyperplastic nodule may be a premalignant lesion, nodular goiter had malignant potential. Key words: Nodular goiter; Hyperplastic nodule; Thyroid cancer; p27 protein

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