Abstract

Objective To explore a novel diagnostic method of normal thyroid,nodular goiter and thyroid cancer by Fourier transform infrared(FTIR) spectrum intraoperatively. Methods Thirty- six cases of FTIR spectra of freshly removed normal thyroid tissues,56 of the nodular goiter and 46 of thyroid cancer were collected.Twenty- nine FTIR parameters of 10 bands including peak position, relative intensity ratio and full width at half maximum(FWHM) were measured.The data were analyzed by one- way ANOVA. Results Lots of FTIR parameters related to nucleic acid, protein, carbohydrate, and lipid were different in a statistically significant way among the three groups.Further Least- Significant Difference(LSD)or Tamhane's T2 test were performed,and the results showed: F1 250 increased in a pairwise way(P<0.05); Compared to other two groups, P1 085 moved to the high wave numbers and I1 085/I1 460 increased significantly in cancer group; F1 460 narrowed while F1 120 widened specifically in goiter group. Conclusion FTIR spectroscopy is a potentially powerful diagnostic tool of thyroid diseases and can be applied intraoperatively in future. Key words: Thyroid disease; Fourier transform infrared; Diagnosis

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