Study of Relation between Advanced Oxidation Protein Product and Bone Mass Density in Type 2 Diabetic Patient

Abstract

Abstract Background Many disorders associated with diabetes, such as oxidative stress, hyperglycemia, and body weight, can be considered to be involved in the pathogenesis of diabetic bone disorder. Among them, oxidative stress may be a candidate, since it is increased under diabetic conditions and is known to induce cellular dysfunction in a wide variety of cell types. Reactive oxygen species (ROS) generated by high glucose concentrations are also considered to be a causal link between hyperglycemia and other metabolic abnormalities in the development of many diabetic complications. Aim of the Work This study evaluated the relation between advanced oxidation protein product and bone mass density in type2 diabetic patient. Patients and Methods This cross sectional study was conducted on 90 postmenopausal female patients aged from 50-60 years old, selected from endocrine outpatient clinic of Ain shams university hospitals for 12 months in a period from May 2019 to May 2020. Results AOPP was significantly higher in group I (diabetic patients) than group II. There were significant correlations between AOPP and (BMI, HbA1c, forearm, femur, spine T-SCORE) in group I and both groups but there were no significant correlations between AOPP and (menopause duration, age, creatinine, urea, eGFR, Ca level, phosphate level and PTH). Conclusion From the results of current study we can conclude that: AOPP is significantly higher in diabetic patient’s more than non-diabetic patients. Higher AOPP levels were associated with lower BMD. BMD of spine was significantly decreased in diabetic patients than other bony parts. AOPP was significantly increased with high BMI, HbA1c level