STUDY OF POTENTIAL ANTITUSSIVE ACTIVITY OF GLYCYRRHIZA GLABRA GRANULES BY USING A COUGH MODEL INDUCED BY SULPHUR DIOXIDE GAS IN MICE

Mayuri Shitole,Vijaykumar Pawar

doi:10.22159/ajpcr.2019.v12i10.33967

Abstract

In respiratory diseases cough is most common symptom. When cough becomes severe, opioids are potent, but they have side effects like sedation, constipation. Therefore, there is a necessary to have effective antitussive formulation, which does not have respiratory depressant activity. The present study was carried out to analysis antitussive activity of Glycyrrhiza glabra L. using a cough model induced by sulphur dioxide gas in experimental mice. The effect of the granules of Glycyrrhiza glabra extract on SO2 gas induced cough in experimental animals have very significant effects at the level of p<0.01 in inhibiting the cough reflex at a dose of 200 mg/kg body weight, in comparison with the control group. Mice were showed an inhibition of 41.17%, in cough on treatment with Glycyrrhiza glabra granules at 60 min experiment. The antitussive activity of the granules was comparable to that of codeine sulphate (10, 15, 20 mg/kg body weight), a standard anti-tussive agent. Codeine sulphate, as a standard drug for suppression of cough, produced 25.29%, 33.33%, 47.13% inhibition in cough at a dose of 10 mg/kg, 15 mg/kg and 20 mg/kg respectively, whereas, codeine sulphate (20 mg/kg) showed maximum 47.13% (p<0.001) inhibition at 60 min of the experiment.

Highlights

A cough, is called as tussis, is a voluntary either involuntary carry through clear the throat as well as breathing passage of foreign particles, fluids, microbes, irritants, and mucus; its a rapid expulsion of air from the lungs, it interferes with quality of life and even cause exhaustion
The antitussive activity of the granules tested in control, standard, and test animal group, respectively, it was compared to standard codeine sulfate (10, 15, and 20 mg/kg body weight [BW])
Statistical analysis shows very significant antitussive effects of G. glabra granules at the level of p

Summary

Introduction

A cough, is called as tussis, is a voluntary either involuntary carry through clear the throat as well as breathing passage of foreign particles, fluids, microbes, irritants, and mucus; its a rapid expulsion of air from the lungs, it interferes with quality of life and even cause exhaustion. Codeine, pholcodine, noscapine, and dextromethorphan are potent, but they have certain constitutional side effects such as sedation, constipation, as well as addiction liability. Their use in serious cough conditions like asthma is contraindicated, as they are known to more compromise the respiratory function. Cough suppressant and antiasthmatic activities have been claimed for many medicinal plants in the literature. On the basis of this knowledge, different workers have assessed botanicals for antitussive/cough suppressant activity, for example, Ocimum sanctum, Passiflora incarnata, Ionidium suffruticosam, Trichodesma indicum, Abies webbiana, Ficus racemosa, Lagerstroemia parviflora, Drymaria cordata, Leucas lavandulaefolia, Jussiaea suffruticosa, and Asparagus racemosus. While that the different medicinal plants would work by different mechanisms of suppressing cough; there are very few studies available on the combined activity of the different medicinal plants [2]

Methods

Results

Conclusion