Abstract
Objective: Perform the histomorphometric study of the following regions: areas of perivillous fibrin deposition; thickness of the endothelial layer of the vessels; analysis of Tenney-Parker changes. Analyze the Placental Index (IP). Results: It was seen that the weight of the placentas increased according to the weight of the newborn, however, when the variable PI was analyzed as being decisive for the development of a risk-free pregnancy, it was found that this parameter was not significant between the groups studied. (p <0.05). It was found that there is a significant difference in relation to the areas of fibrin deposition (P <0.05) between the groups and that it possibly converges with the data found in the literature in which it could be established that in the GrH there is a different relationship in this pattern. The findings of the thickness of the middle layer were significant in the GrH when compared to the GrN (p <0.05), when this parameter is compared between the Hypertensive Disorders of Pregnancy (HDP) groups, microscopically the PE cases showed prominent changes. I n the present study, Tenney-Parker changes were prominent and discreet in 75% of the GrH placentas versus 20% in the GrN. However, there are contradictions in the literature regarding the consideration of this finding seen only in Hematoxylin-Eosin staining. Conclusion: Given the above, the presence of syncytial knots, the difference between vessel thickness and areas of fibrin deposition are possibly involved in the pathogenesis of Hypertensive Syndromes, regardless of age and established classifications. In order to evaluate syncytial knots, further studies are needed in this population.
Highlights
In pregnancy, there are several physiological and psychological adaptations, and according to each pregnant woman there may be development of pathologies, such as, for example, Hypertensive Disorders of Pregnancy (HDP) (BRASIL, 2012)
According to the High Risk Pregnancy Manual (BRASIL, 2012), HDP corresponds to a blood pressure (BP) level equal to or greater than 140/90 mmHg, possibly accompanied by proteinuria, that is, excretion of 0.3 g of proteins or more obtained exclusively by a 24-hour urine the hypertensive group (GrH) assisted in two public maternity hospitals, establishing comparative analyzes with a normotensive group (GrN)
TenneyParker changes or Syncytial knots, that is, clusters of syncytiotrophoblast nuclei or syncytialknots, were identified as prominent, discrete or absent (ARTICO et al, 2009) that may arise in response to the pathophysiological mechanisms of hypertensive syndromes resulting from placental aging early (GÓMEZ, The placentas were sent to the Laboratory of 2018)
Summary
There are several physiological and psychological adaptations, and according to each pregnant woman there may be development of pathologies, such as, for example, Hypertensive Disorders of Pregnancy (HDP) (BRASIL, 2012). According to the High Risk Pregnancy Manual (BRASIL, 2012), HDP corresponds to a blood pressure (BP) level equal to or greater than 140/90 mmHg, possibly accompanied by proteinuria, that is, excretion of 0.3 g of proteins or more obtained exclusively by a 24-hour urine the hypertensive group (GrH) assisted in two public maternity hospitals, establishing comparative analyzes with a normotensive group (GrN).
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