Abstract
Microbial infections have targeted millions of victims in human history. In spite of the great efforts that are being continuously made to find effective medication, still no drug exists that can truly cure and have no side effects for the said infections. Amongst the drugs that are available in the market for microbial infections, 1,3,4-thiadiazole derivatives have found to have extensive pharmacological activities and further optimized for other diseases [1,2]. Efforts are done to synthesize various carboxylic acid derivatives of 1,3,4 thiadiazol and to study their pharmacological activities [1,2]. In this research article, comparative study of various previously synthesized carboxylic acid derivatives of 1,3,4 thiadiazol is done using their pharmacophore modeling to identify the prominent structural features [1]. The analysis indicates that the synthesized molecules have specific hydrogen acceptor, hydrogen donor and lipophilic centers with some variations.
Published Version
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