Abstract
The solubilities of five sparingly soluble drug-compounds in water have been measured at constant temperatures (298.1K and 310.1K) by the classical saturation shake-flask method. All substances presented in this work are derivatives of anthranilic acid: flufenamic acid, (FLU), mefenamic acid, (MEF), niflumic acid, (NIF), diclofenac sodium, (DIC), and meclofenamic sodium, (MEC). All of them have anti-inflammatory action. Since the aqueous solubility of the ionized drug is significantly higher than the unionized, the experimental conditions that affect equilibrium solubility values such as composition of aqueous buffer have been examined. The Henderson-Hasselbalch (HH) relationship has been used to predict the pH-dependent solubility profiles of chosen drugs at two temperatures. For this purpose the pKa values of the investigated drugs have been determined with Bates-Schwarzenbach spectrophotometric method at temperature 310.1 K. At temperature 298.1K these values were reported earlier. Similar values of pKa were obtained from the solubility measurements.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Chemical Industry and Chemical Engineering Quarterly
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
