Nifumic Acidの薬理学的研究特にFenamate類との比較(第1報)

Abstract

Anti-inflammatory and analgesic effects of niflumic acid, 2-arylamino-nicotinic acid corresponding to anthranilic anti-inflammatory agents, were studied by a detailed analysis in comparison with fenamates (flufenamic acid and mefenamic acid). Niflumic acid showed similar inhibitory effects on the increased vascular permeability to flufena-mic acid and a stronger effect than mefenamic acid. In the acute edema test induced by various phiogists, niflumic acid had the same potent anti-edematous properties as fena-mates and phenylbutazone. In the subacute edema test induced by mustard, niflumic acid showed an inhibitory effect similar to flufenamic acid which had stronger effect than mefenamic acid. When the inhibitory effects on the proliferation of granulation tissue were tested by cotton-pellet and granuloma pouch methods, niflumic acid was more potent than mefenamic acid, but somewhat less than flufenamic acid and phenylbuta-zone. Niflumic acid had potent inhibitory action similar to fenamates on the ultra-violet erythema, but the effects of niflumic acid and mefenamic acid on the adjuvant arthritis were weaker than that of flufenamic acid. The analgesic action of niflumic acid was similar to that of mefenamic acid which was more potent than flufenamic acid and phenylbutazone. From the above results, niflumic acid was proved to have similar effects to flufena-mic acid and a more potent effect than mefenamic acid on acute inflammation, but similar effects to mefenamic acid and less than flufenamic acid on the subacute or chronic inflammation. Furthermore, it was similar to mefenamic acid and more potent than flufenamic acid regarding analgesic actions. It may, therefore, be considered that niflumic acid has a clinical application similar to mefenamic acid as a non-steroid anti-inflammatory agent.