Abstract
Background: Pregnancy induced hypertension is a leading cause of morbidity and mortality in pregnant woman. Preeclampsia and Eclampsia Sepsis and Haemorrhage are the prime killers in pregnancy.Aim: This study is aimed to assess the role of oxidative stress by estimating Malondialdehyde(MDA), Glutathione s-transferase (GST) and its severity by estimating serum uric acid levels in PIH.Materials and Methods: The study comprised of 60 third trimester pregnant woman . Among those 24 were clinically diagnosed Preeclamptic cases ,16 were Eclamptic cases and 20 were Normotensive antenatal controls. Plasma MDA, GSTlevels and serum uric acid levels were estimated and compared in them.Results: Mean values of plama MDA, GST and serum uric acid levels in cases were 5.14 1.88nmol/ml, 44.49 14.48IU/L,, 7.211.63mg/dL and in controls mean values were 1.70.87nmol/ml, 70.9812.68IU/L, 4.381.24mg/dL respectively.Conclusion: Mean values of plasma MDA, serum Uric acid levels were significantly higher and plasma GST levels were significantly lower in pregnancy induced hypertension cases when compared with normotensive antenatal controls
Highlights
Pregnancy induced hypertension (PIH) is a leading cause of fetal growth retardation, infant morbidity, mortality and maternal death
Preeclampsia is characterized by a clinical trial of Hypertension (>140/90 mm of Hg), proteinuria and edema developed after 20 weeks of gestation
Present study was carried out in Department of Biochemistry and Department of Obstetrics and Gynecology of S.V Medical College Tirupati on a total of 60 pregnant women in third trimester. Among those 24 were clinically diagnosed Preeclamptic cases, 16 were eclamptic cases and 20 were Normotensive age matched antenatal controls. 2.1 Inclusion criteria Cases: Pregnant woman in third trimester clinically diagnosed to have PIH with blood pressure >140/90 mm of Hg on 2 separate occasions more than 6 hrs apart with bilateral pedal edema, proteinuria are taken as preeclampsia cases and those with overwhelming convulsions as eclampsia cases
Summary
Pregnancy induced hypertension (PIH) is a leading cause of fetal growth retardation, infant morbidity, mortality and maternal death. Pregnancy induced hypertension is a leading cause of morbidity and mortality in pregnant woman. Aim: This study is aimed to assess the role of oxidative stress by estimating Malondialdehyde MDA), Glutathione –s-transferase (GST) and its severity by estimating serum uric acid levels in PIH. Materials and Methods: The study comprised of 60 third trimester pregnant woman Among those 24 were clinically diagnosed Preeclamptic cases, 16 were eclamptic cases and 20 were Normotensive antenatal controls. Conclusion: Mean values of plasma MDA, serum Uric acid levels were significantly higher and plasma GST levels were significantly lower in pregnancy induced hypertension cases when compared with normotensive antenatal controls.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Biomedical and Advance Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
