Abstract
The purpose of this research is to see if there is a link between diabetes type 2 complications and the level of nuclear factor kappa B (NF-κB) overexpression.
 Ninety blood samples were collected from individuals and divided into three groups, each group involved thirty samples: the first group representing individuals with (hypertensive type 2 diabetes ) ,the second group representing (hypertensive type 2 diabeteswith cardiovascular diseases), and the last group was represented by a control group.
 mRNA was extracted from blood samples then converted to cDNA by using the (qPCR) technique. The outcomes revealed a significant increase (p<0.05) in expression of mRNANF-κB in both groups compared to the control group and this over- expression in hypertensive type 2 diabetes with cardiovascular diseases more than hypertensive type 2 diabetes. The NF-κB gene was studied in type 2 diabetes and cardiovascular disease in the current study, and it could be a novel target for early CVD therapy in the future.
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