Abstract
A synthesis of nano-hydroxyapatite:polylactide acid (n-HA:PLA) composites based on natural materials has been performed. The synthesis was performed using sonication method, with a variation of n-HA:PLA ratio of 90:10, 80:20, 70:30, 60:40, 50:50 in %wt. The crystal structure and morphology of the sample were characterized by using X-ray diffractometer (XRD) and scanning electron microscopy (SEM). The bioactivity and biodegradable tests were performed in vitro using Krebs solution. Meanwhile, the biocompatibility test was performed by a separate bath organ method. The results show that for all compositions of n-HA:PLA exhibit a biocompatible characteristic. The sample with a ratio of 90:10 %wt shows higher bioactivity and biodegradability properties than other compositions. Our result would give a good understanding of the synthesis and biocompatibility, bioactivity, and biodegradability of n-HA:PLA composite, which is crucial for bone regeneration.
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