STUDY OF MUTATIONS IN THE mmpR AND atpE GENES ASSOCIATED WITH THE DEVELOPMENT OF MYCOBACTERIUM TUBERCULOSIS RESISTANCE TO BEDAQUILINE

Abstract

In the study we obtained and analyzed the results of the development of resistance of Mycobacterium tuberculosis to the novel antitubercular drug bedaquiline. We investigate 16 strains isolated from 16 patients with pulmonary TB after bedaquiline therapy. With the help of wholegenome sequencing we detected 20 mutations in the mmpR gene and 6 mutations in the target gene atpE associated with bedaquiline resistance in vitro. It was found, that MIC values of bedaquiline were significantly higher for strains with mutations in the atpE gene than for MTB strains with mutations in the mmpR gene.