Study of malignant germ cell tumors with special reference to malignant ovarian germ cell tumors: 5 years experience

R Jha,S Jha

doi:10.3126/jpn.v2i4.6880

Abstract

Background: Germ cell tumors are rare and complex group of heterogenous neoplasms that comprise both benign and malignant histology. The testes and ovaries are the most common sites. This descriptive study focused on distribution of malignant germ cell tumors with more detail study of ovarian malignant germ cell tumors.Materials and Methods: All cases of malignant germ cell tumor reported from department of pathology of Tribhuvan University Teaching Hospital over five years from April 2007 to April 2012 were included in the study.Results: Thirty five cases (24 female and 11 male) were diagnosed as having malignant germ cell tumors. Most patients were below 30 years of age. Ovary was the most common site followed by testes. Malignant ovarian germ cell tumor comprised 54.3% of all malignant germ cell tumors. Age of these patients ranged from 6 years to 32 years. Most common histologic type was yolk sac tumor.Conclusion: Malignant germ cell tumors can be seen in any age group from new born to old age. However malignant ovarian germ cell tumors occur mainly in first three decades of life, are mostly unilateral and are of large size at the time of diagnosis due to rapid growth. However these tumors are often of low stage and managed with conservative surgery.Journal of Pathology of Nepal (2012) Vol. 2, 289-292DOI: http://dx.doi.org/10.3126/jpn.v2i4.6880

Highlights

Germ cell tumors (GCT) are a rare and complex group of heterogenous neoplasms that comprise both benign and malignant histologies
Ovary was the most common site (54.3%) of malignant germ cell tumors (MGCT) followed by testes (22.9%)
Most common histologic type was YST (28.6%) which showed reticular pattern with several extracullar eosinophilic hyaline globules. This was followed by mixed germ cell tumor and immature teratoma.(Table 2) Size of the tumor ranged from 2.5 to 25 cm

Summary

Introduction

Germ cell tumors (GCT) are a rare and complex group of heterogenous neoplasms that comprise both benign and malignant histologies. Despite their heterogeneity, they are all presumed to arise from totipotent primordial germ cells (PGC). A mixture of histologic subtypes may be present within any single GCT suggesting a close interrelationship between different histologies and the cell of origin.[1] The testes and ovaries are the most common sites where GCTs occur. Germ cell tumors are rare and complex group of heterogenous neoplasms that comprise both benign and malignant histology. The testes and ovaries are the most common sites This descriptive study focused on distribution of malignant germ cell tumors with more detail study of ovarian malignant germ cell tumors

Methods

Results

Discussion

Conclusion