Abstract
Selected nicotinic acid derivatives have been chromatographed on RP-HPTLC plates with methanol-water in different volume proportions as mobile phases. Linear relationships were obtained between R M values of nicotinic acid derivatives and the volume fraction of methanol in the mobile phase. The retention values R M were extrapolated to zero methanol content and the lipophilicity values R M0 obtained were compared with measured (log P exp ) partition coefficients and values ( A log P s, IA log P , C log P , log P Kowin , and x log P ) calculated by use of five different software products. A linear relationship was obtained between R M0 and the slope, S , of the chromatography equation. The most significant correlation was found between the R M0 and A log P s values. For the nicotinic acid derivatives R M0 was a slightly better measure of lipophilicity than ϕ 0 . Chromatographic R M0 values can be use as a measure of the lipophilicity of the nicotinic acid derivatives investigated. Satisfactory linear corre...
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