Abstract
Ergocalciferol, cholecalciferol, (±)-α-tocopherol, tocopherol acetate, retinol, retinol acetate, retinol palmitate, menadione, and phytonadione have been investigated on RP8F 254s and RP18F 254s TLC plates with methanol-water in different volume proportions as mobile phases. Linear relationships were obtained between the R M values of the fat-soluble vitamins and the volume fraction of methanol in the mobile phase. Retention values, R M , were extrapolated to zero methanol content and the lipophilicity values R MW(RP8) and R MW(RP18) obtained were compared with measured partition coefficients (log P exp ) and partition coefficients (AlogPs, AClogP, AB/logP, COSMOFFrag, milogP, Kowwin, xlogP) calculated using seven different software products. Cluster analysis was also used for comparison of the theoretical partition coefficients with the chromatographic lipophilicity ( R MW(RP8) and R MW(RP18) ) of the fat-soluble vitamins. It was found that lipophilicity values R MW(RP8) were most similar to AClogP where...
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