Study of lesions in reimplanted kidneys preserved by hypothermic storage and perfusion with solution of the extracellular type.

Abstract

The consequences of preservation by solution of extracellular composition were examined in 24 renal autografts. Nine animals survived for indefinite period. In the reimplanted kidneys of the animals which had died in the acute phase (1st to 7th day) gross oedema, haemorrhages, lesions of tubular epithelium and glomerular congestion were prevalent. In later stages (23rd to 43rd day) the renal structure was well preserved in some places and there were extensive fibrous peritubular areas. In the kidneys of the long-term survivors the fibrous tissue resulting from irreversible destruction was confined to small areas. It is concluded that, though some degree of tissue destruction is inevitable, it is possible to minimize it by using appropriate preserving solutions.