Abstract
We studied the influence of L-carnitine in a dose of 300 mg/kg on the aorta, myocardium and skeletal muscle of the anterior thigh of rats in isolation and in combination with regulators of the synthesis of nitric oxide: L-arginine, L-NAME. Activity of cathepsins B, L and H were studied by spectrofluorimeter method: in sedimentated and non-sedimentated fractions. Oxidative modification of proteins was evaluated by the method of R. L. Levine in modification of E. E. Dubinina. There was an inverse statistically significant strong correlation between the total area of modified proteins and non-sedimentated activity of cathepsin H in the area of the aorta under the action of the isolated carnitine at a dose of 300 mg/kg; and in the influence of L-NAME at a dose of 25 mg/kg, against the use of carnitine 300 mg/kg notes statistically significant strong direct correlation between change of total area оxidative modification of proteins and non-sedimentated activity of cathepsin L.
Highlights
Изучено влияние L-карнитина в дозе 300 мг/кг на аорту, миокард и скелетную мышцу переднего бедра крыс, изолированно и в сочетании с регуляторами синтеза оксида азота: L-аргинин, L-NAME
We studied the influence of L-carnitine in a dose of 300 mg/kg on the aorta, myocardium and skeletal muscle of the anterior thigh of rats in isolation and in combination with regulators of the synthesis of nitric oxide: L-arginine, L-NAME
Activity of cathepsins B, L and H were studied by spectrofluorimeter method: in sedimentated and non-sedimentated fractions
Summary
Изучено влияние L-карнитина в дозе 300 мг/кг на аорту, миокард и скелетную мышцу переднего бедра крыс, изолированно и в сочетании с регуляторами синтеза оксида азота: L-аргинин, L-NAME. Статистически значимый рост покафенилгидразонов нейтрального характера зателей группы животных с применением (S АДНФГuv) и основного (S АДНФГvs); и карнитина относительно контрольной кетон-динитрофенилгидразонов нейтраль- группы, свидетельствует о выраженном ного (S КДНФГuv) и основного характера (S КДНФГvs); а также их общую сумму нарастании окислительной модификации (табл.1).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
