Abstract
Background Although abnormal fatty deposits of infected arterial plaque play a major role in the formation of atherosclerotic plaque, activation of inflammatory cells plays a major role in the instability of the plaque and the cause of acute coronary syndrome. The aim of this study was to measure the level of interleukin-6 and to study its association with complications that occur in hospital in patients with acute coronary syndrome. Method: One hundred and twenty-five patients with acute coronary syndrome and 120 healthy individuals as a control group were included in this study. According to ECG and serum troponin changes, the patient group was classified into three ST-elevated myocardial infarction, ST non-elevated myocardial infarction and unstable angina. Sandwich ELISA was used by commercial groups (LEGAND MAX TM) for the IL-6 assay. Result: This study shows significantly significant differences in the level of IL-6 in patients with acute coronary syndrome (73.37 pg / dL) compared to the control group (9.47 pg / dL) (P value 0.001) There were no significant differences at the level of IL-6 in patients with acute coronary syndrome and conventional risk factors (P. value <0.05). There were significant differences in the level of IL-6 in all forms of ACS. (P. value 0.001). And those patients who had complications in hospital had a higher IL-6 level (92.89 Pg / dl) than those without complications (68.83 Pg / dl) P. value (0.012). Conclusion: This study indicated that IL-6 was significantly elevated in ACS patients
Highlights
Cardiovascular disease is the most common cause of death worldwide and among cardiovascular deaths; The vast majority are attributed to acute coronary syndrome
This study showed that ST elevation myocardial infarction (STEMI) was the commonest form of ACS observed in 75(60%) of patients (Figure 1, Table 1)
A statistically significant differences in IL-6 level in all forms of ACS (STEMI, Non-ST elevation myocardial infarction (NSTEMI) and UA) in comparison with control group P. value (0.001,0.001,0.04 respectively) were reported in this study and that were come in agreements with other researches finding [20,21,22,23]
Summary
Cardiovascular disease is the most common cause of death worldwide and among cardiovascular deaths; The vast majority are attributed to acute coronary syndrome Fissuring or rupture of these plaques and consequent exposure of core constituents such as lipid, smooth muscle, and foam cells leads to the local generation of thrombin and deposition of fibrin. This in turn promotes platelet aggregation and adhesion and the formation of intracoronary thrombus [7]. Result: This study shows significantly significant differences in the level of IL-6 in patients with acute coronary syndrome (73.37 pg / dL) compared to the control group (9.47 pg / dL) (P value 0.001). There were no significant differences at the level of IL-6 in patients with acute coronary syndrome and conventional risk factors (P. value
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