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Abstract
Nanoceria have shown numerous unique characteristics, such as biocompatibility and are excellent agents for biological applications. The aim of this study is to investigate cerium oxide nanoparticles for 2, 2- diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging activity and their ability to offer protection against ionizing radiation. In vitro antioxidant activity study of nanoceria particles has shown good free radical scavenging activity for DPPH radical assayed within a concentration range of 0.01 to 0.05 g/l, at higher concentrations of nanoparticles showed reverse trend in absorbance and inhibition indicating this finite rang of concentration is suitable for scavenging free radicals, also nanoparticles were found to have significant antioxidant capacity and thus can be used as potential radical scavenger against deleterious damages caused by the free radicals. The results of histopathological examination showed effectiveness of CeO2 nanoparticles in radioprotection of skin cells in animal models during radiation exposure.
Highlights
Living organisms are continuously exposed to ionizing radiations from natural radiation
In order to investigate in vitro antioxidant activity of nanoceria, this work were carried out in two experiments with a range of CeO2 NPs concentrations added to the samples before irradiation to prevent free radical formation and added after irradiation to scavenge free radicals and reduce their risk
DPPH is a stable organic free radical which is widely used as a substrate to evaluate antioxidant activity of different compound
Summary
Living organisms are continuously exposed to ionizing radiations from natural radiation. Exposures occur as a result of human activities and medical practices. Radiations are broadly categorized into natural and man-made sources. Manmade radiation exposure to populations occurs mainly from medical uses of radiation and radioisotopes in health care. Use of ionizing radiation in medical diagnosis and therapy is widespread and constantly increasing due to useful newer health care applications. Ionizing radiation may be divided into directly and indirectly ionizing for the understanding of biological effects [1]. Electromagnetic radiations, x and rays, are indirectly ionizing because they do not produce chemical and biological damage themselves but produce secondary electrons (charged particles) after energy absorption in the material
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