Abstract
The article presents experimental materials on the effect of a synthetic adjuvant on the hematological parameters of the blood of laboratory animals, depending on the method of administration. Currently, the search continues for new effective vaccine preparations based on polymeric compounds with immunostimulating properties. An important condition for development of certain carriers (adjuvants) is creation of a drug that can stay in the body for a long time and not cause development of inflammatory reactions, and also does not affect the biochemical and hematological parameters of the blood of animals.
Highlights
The study of adjuvants dates back to the 20s of the XIX century, when Gaston Ramon showed the possibility of enhancing the humoral immune response by introducing additional substances – adjuvants.Adjuvants are used to increase the immunogenicity of highly purified bacterial and viral antigens, toxoids, recombinant and synthetic antigens, and etc
In the blood of mammals, the main function of erythrocytes is the transport of respiratory gases, since with this form the diffusion surface increases and the diffusion distance decreases
Our studies have shown that the number of erythrocytes in animals of the control group is (6.8 ± 0.2) 1,012/l, and in the experimental groups with oral administration (6.69 ± 0.29) 1,012/l, with intramuscular (6, 59 ± 0.21) 1,012/l, with subcutaneous administration (6.59 ± 0.21) 1,012/l
Summary
Adjuvants are used to increase the immunogenicity of highly purified bacterial and viral antigens, toxoids, recombinant and synthetic antigens, and etc. Inclusion of adjuvants in the composition of vaccines provides a faster formation of pronounced and long-term specific immunity. The expediency of using adjuvants in vaccines is to increase the immunogenicity of vaccines, change the nature of the immune response, reduce the amount of antigen required for successful immunization, reduce the frequency of vaccine administration and increase the intensity of the immune response in animals with reduced immunological activity [1,5]. Together with scientists from SSU named after N.I. Chernyshevsky developed a new adjuvant based on a chemical polyelectrolyte substance. It is planned to use it in the composition of vaccines
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