Abstract
The study was conducted to detect possible changes in embryogenesis and negative effects of third generation antihistamine – desloratadine – after intranasal administration of 1.3 mg/m 3 and 13.0 mg/m 3 of the substance to laboratory animals during their prenatal period. In these circumstances, desloratadine does not cause any significant changes of embryogenesis parameters . Macroscopic examination of the fetus and placenta in animals of experimental groups did not reveal any pathology or physiological deviations from the norm. 13.0 mg/m 3 concentration of the drug caused a decrease in the weight of embryos in comparison with control group of animals and physiological data , despite a well developed, without visible pat h ology, placenta. This neces sitates a n in-depth study o f possible teratogenic effects of intranasally administred desloratadine to laboratory animals.
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