Study of Carcinoma Embryonic Antigen (CEA) and its Relationship to TSH Polymorphisms in Patients with Thyroid Gland Dysfunction.

Abstract

In this study, 145 patients with different thyroid dysfunctions were included. All the patients have undergone for measuring thyroid hormone (T3, T4 & TSH). These patients are put in five groups, in the first group, which include 38 patients who have hyperthyroidism, the second group includes 58 patients who have hypothyroidism, the third group includes 31 patients who have Euthyroid with normal thyroid hormones levels, the fourth group includes 5 patients only who have low levels of thyroid hormones, and the last group includes 13 patients who have a high levels of TSH with normal level of T3 & T4. All samples are obtained before treatment. All serum samples are subjected to estimate the levels of CEA. The results of this study showed that CEA is increased at high levels in patients of group 2 & group 5 who have high levels of TSH. However, some patients when the treatment is given, CEA levels return to the normal. This will give an indicator that CEA is not biomarker for malignancy but it is a biomarker for the high TSH levels associated with two groups (two and five). Single nucleotide polymorphism was studied for D1a gene to show the variation between TSH & CEA levels in patients with thyroid dysfunction .The study was found that the genotype is C/C allele which gives absolute relationship between TSH concentration and CEA levels in both patients and control groups and to the less extent in heterozygous allele C/T.