Study of C - reactive protein, D-dimer in correlation with HbA1C levels in patients with diabetes mellitus type 2

Abstract

: Diabetes Mellitus is a chronic metabolic disease presented with chronic hyperglycemia, which causes abnormalities in the endothelial cells, proinflammatory state, altered platelet function & plasma coagulation factors that lead to a hypercoagulable state & thrombotic incidents. D-dimer is an indirect marker of thrombotic activity. C-reactive protein (CRP) is an important risk factor for systemic inflammation, so the present study aimed to determine the relationship between CRP, D-dimer in correlation with HbA1C in patients with Diabetes Mellitus. The present study is undertaken to evaluate the study of D-dimer, C-reactive protein in correlation with HbA1C levels in Type 2 Diabetes Mellitus. : A total of one hundred & twenty subjects aged 30-70 years were included. The patients were selected from those who attended the medical OPD at Gandhi Medical College & hospital, Secunderabad, & their samples are analyzed by Beckmann Coulter Fully Automatic Analyzer AU5800. CRP is estimated by rate turbidimetry method & D-dimer is estimated by rate turbidimetry method. HbA1C by HPLC in Bio-rad-D-10: The prospective of elevated D-dimer, CRP levels are in correlation with increased HbA1C levels. So screening of inflammatory & hemostatic markers must be done in patients with uncontrolled Diabetes Mellitus.