STUDY OF ANTIHYPERTENSIVE DRUG UTILIZATION PATTERN IN CHRONIC KIDNEY DISEASE PATIENTS

Abstract

Introduction: Hypertension is a chronic illness associated with high morbidity & mortality, with a rising number of patients with hypertension and chronic kidney disease, achieving blood pressure of less than 140/90 mm of Hg is challenging. Hence, there is a need for appropriate, safe, effective and economical study to find out the patterns of drug therapy. Objectives: To evaluate utilization patterns of antihypertensive agents in chronic kidney disease patients. Methodology: A prospective observational study was conducted for a period of 6 months in Jayanagar General Hospital, Bengaluru. We included 70 hypertensive CKD patients. Detailed patient information data were noted, and data entered in a preformed proforma in Microsoft Excel sheet for compilation and subjected to statistical analysis. Results: Total 70 case records of patients having chronic kidney disease were analysed. Mean age was 52.08 ± 15.14. CKD was more prevalent in males 38 (54.2%) and 32 (46.8%) females with male to female ratio of 2.3:2. Most of the patients (52.80%) belonged tote age group of 41-60 years. Among the anti-hypertensive agents, most frequently used was calcium channel blockers (91.4%), followed by diuretics (54.2%), Beta blockers (31.4%), alpha blockers, ACE inhibitors and ARB. Conclusion: Dual and triple therapy were prescribed which was according to ESH guidelines. This study highlights some therapeutic rationality in this health centre. However, Int. J. Drug Res. Tech. 2019, Vol. 9 (3), 252-270 ISSN 2277-1506 www.ijdrt.com 112 targeted education of the prescription-givers and dissemination of treatment guideline could facilitate rational use of drugs and adherence to treatment guidelines.