Abstract
Diabetes mellitus is a metabolic disorder in which there is defect in insulin secretion high blood sugar levels over a prolonged period. The polyherbal extract under study contain extract of Eugenia jambolana (seed) , Citrulus colocynthis (fruit), Terminaliachebula ( Fruit) , Curcuma amada (Rhizome) , Syzigium cumini ( seed) in combination shows decrease in levels enhace gluconeogenesis from protein and Amino acid with accumulation of glycogen in liver. Crude drugs like Eugenia jambolana, Mamordica charantia, Terminalia Chebula, and Black cumini increase secreation of insulin from B-cells of islets of pancrease. The proposed study is to investigate the effectiveness that of combination of these herbs as a polyherbal extract formulation in treatment of type II diabetic model. In the present study, experimental diabetes was induced Alloxan dose 150 mg/kg(Group ll), Diabetic standard diabetic rats were treated with oral dose of (metformin) 10mg/kg (Grouplll), group iv, v, vi) Diabetic rats were treated with an polyherbal extract 50mg/kg, 100mg/kg, 150mg /kg respectively. Drugs Metformin and polyherbal extract were given once in daily. The dietry regimen for 21 days, during which blood glucose level and lipid profile measured at 0,7,14,21 day of study using blood from rats retroorbital plexus. A high dose (200 mg/kg) of polyherbal extracts treatment group produce significant decrease in plasma glucose level.
 Keywords: Diabetes, Eugenia jambolana, Citrulus colocynthis, Mamordica charantia, Gymnema stylvestre
Highlights
Diabetes mellitus is one of the major disorders which are affecting the world’s major population including the most vulnerable group like geriatrics and pediatric’s population
Experimental diabetes was induced Alloxan dose 150 mg/kg(Group ll), Diabetic standard diabetic rats were treated with oral dose of 10mg/kg (Grouplll), group iv, v, vi) Diabetic rats were treated with an polyherbal extract 50mg/kg, 100mg/kg, 150mg /kg respectively
Metabolic disease characterized by elevated levels of blood glucose, which leads over time to serious damage to the heart, blood vessels, eyes, kidneys and nerves
Summary
Diabetes mellitus is one of the major disorders which are affecting the world’s major population including the most vulnerable group like geriatrics and pediatric’s population. People living with type 2 DM are more vulnerable to various forms of both shortand long-term complications, which often lead to their premature death This tendency of increased morbidity and mortality is seen in patients with type 2 DM because of the commonness of this type of DM, its insidious onset and late recognition, especially in resource-poor developing countries like Africa [2,7]. This metabolic disorder is characterized by hyperglycaemia and disturbances of carbohydrate, protein and fat metabolisms, secondary to an absolute or relative lack of the hormone insulin [1]. There is a globally agreed target to halt the rise in diabetes and obesity by 2025
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