Abstract
1. 1. Since propylthiouracil-induced hypothyroidism in the mash (commercial high carbohydrate diet) fed chick results in liver enlargement with excessive accumulation of glycogen, these studies were conducted to determine the effect of diet composition on carbohydrate and lipid metabolism in the hypothyroid chick. 2. 2. PTU (0.1%) was fed for 2 weeks in mash, high carbohydrate (HC), high fat (HF), or in high protein (HP) diets. 3. 3. Thyroid glands were significantly enlarged in all PTU treated chicks independent of the nature of dietary composition. 4. 4. Liver weight increased and glycogen accumulated in all hypothyroid chicks, the maximum in HC diet and minimum in HF diet fed group. 5. 5. Plasma glucose levels did not correlate with liver glycogen concentrations. 6. 6. Hypothyroidism significantly increased plasma triglycerides in HC and mash fed, cholesterol in mash fed and phospholipids in HC and HF diets fed groups. HP diet had a hypocholesterolemic effect. 7. 7. PTU significantly decreased bile phospholipids. Bile cholesterol was also decreased except in HF diet fed group. 8. 8. The results demonstrate profound changes in carbohydrate and lipid metabolism in hypothyroid chicks. These changes are modulated by dietary composition and liver glycogen accumulation probably is dependent on dietary carbohydrate supply.
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