Abstract
For the hyperthermia therapy of cancer, ferrimagnetic glass ceramics are a potential candidate. Ferrimagnetic zinc-ferrite-containing bioactive glass ceramics were prepared by quenching the glass ceramics from sintering temperature. Then the samples were heated to 600°C and cooled in an aligning magnetic field of 1 Tesla to cause anisotropy. The magnetically aligned samples were compared with non-aligned samples. Vibrating sample magnetometry measurements at 10 kOe showed that the magnetic properties were enhanced by the aligning magnetic field and it led to an enhancement of the magnetic heat generation under a magnetic induction furnace operating at 500 Oe and 400 kHz for 2 min. Data showed that the maximum specific power loss and temperature increase after 2 min were 31.5 W/g and 45°C, respectively, for the aligned sample of maximum zinc-ferrite crystalline content. The glass ceramics were immersed in simulated body fluid for 3 weeks. X-ray diffraction and Fourier transform infrared and atomic absorption spectroscopy results indicated the growth of precipitated hydroxyapatite, suggesting that the ferrimagnetic glass ceramics were bioactive and could bond to living tissues in physiological environment.
Published Version
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