Study of a tooth gel formulation for hygiene and oral sequelae management in irradiated patients

Ana C.f Ribeiro ,Marina Vieira Da Silva ,Harley Da Silva Tavares ,Ana Margarita Díaz Solano ,Ana M P Gomes

doi:10.7324/japs.2020.10615

Abstract

Enhancement of Dissolution Rate and Formulation Development of Efavirenz Tablets Employing Starch Citrate-A New Modified StarchK.P.R. Chowdary and Veeraiah Enturi

Highlights

Among the most frequent cancers, there are head and neck neoplasms, which include oral and nasal cavities, face, pharynx, larynx, and salivary glands
It is suggested that the proposed formulation (PF) has a singular composition and physicochemical quality to be used as a suitable dentifrice for patients undergoing anticancer therapy
The dentifrice is a product of external use, the oral mucosa of individuals with cervical–facial cancer is profoundly compromised by radiotherapy treatment with or without chemotherapy

Summary

Introduction

Among the most frequent cancers, there are head and neck neoplasms, which include oral and nasal cavities, face, pharynx, larynx, and salivary glands. Its therapeutic compliance can bring innumerable sequelae to the patient, being systemic or restricted to the oral cavity (Jawad et al, 2015; Strojan et al, 2017). On reaching the salivary glands, there is an expressive reduction in the amount and quality of the saliva, which loses its antimicrobial, buffering, and dental remineralization potential. The progressive salivary reduction, besides promoting the proliferation of microorganisms in the oral environment, induces a variety of complications, which initially are noninfectious, such as hemorrhage, mucositis, dry mouth, hypogeusia, osteoradionecrosis, lockjaw, dermatitis, and later dental caries, oral candidiasis, and infections (Neville et al, 2016; Sciubba and Goldenberg, 2006)

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