Abstract
The thyroid function of euthyrotic, hypothyrotic and hyperthyrotic rats was studied before and after a 2 weeks' LiCl treatment. 1. 1. The weights of the adenohypophyses, neurohypophyses, adrenals and especially thyroid glands were greater in Li-treated hypo- or hyperthyrotic animals. 2. 2. Serum protein-bound iodine levels were unaffected by Li. 3. 3. The neck 131I uptake values showed that Li decreased the uptake in euthyrotic animals but increased it in all the other groups. When the mass of the thyroid lobe was taken into consideration, Li increased the uptake in the control and hyperthyrotic animals. 4. 4. In electrophoretic analysis Li caused an increase of thyroidal inorganic iodine in all groups. Chromatographically it was noticed that Li decreased the formation of iodothyronines. The results suggest that Li increases thyroidal iodide, which decreases the formation of T 4 and T 3. The goitrogenic effect of Li seems to be augmented by a previously pathologic thyroidal state.
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