Abstract
A short and stereoselective synthesis of the C 33C 42 fragment 3 of rapamycin and its coupling with the previously prepared C 22C 32 fragment 2 is described. The synthesis of 3 involves the preparation of enantiomerically enriched methylene cyclohexane derivative 7, followed by side-chain elaboration. The coupling is made by reaction of the lithio anion of the dithioacetal monosulfone 11 on the epoxide 3.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.