Abstract
spinal cord dorsal column crush (Lin CY et al. J Neurotrauma. doi:10.1089 /neu.2011.2059 [published online October 24, 2011]). The pain relief lasted for 8 months, which is equivalent to 25 years in humans. “This is the longest and strongest inhibition ever reported for pain treatment in animals,” she said. The inspiration for this approach comes from the injury itself. Fibronectin is a naturally occurring protein known to support the survival and growth of neurons in the brain and spinal cord. Prior work has shown that after an injury, fibronectin can stimulate axonal growth, regulate inflammation, reduce tissue loss, and in some cases improve functional outcome. Spinal cord injury increases the permeability of the blood–spinal cord barrier, and there is evidence that fibronectin maintains the integrity of this barrier. No apparent adverse effects were seen with this treatment. The long-term goal, said Lin, is to understand the underlying mechanism at work and to develop fibronectin as a treatment for spinal cord injury pain in humans.
Published Version
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