Abstract
N-(2-Acyloxyethyl)-N, N-dimethyl-N-(1, 3-dioxolan-2-and 4-ylmethyl) ammonium compounds were synthesized and tested for anticholinergic activity. It was found that among these compounds the N-(2-acyloxyethyl)-N-(1, 3-dioxolan-2-ylmethyl) ammonium derivatives exhibited more potent activities than the N-(2-acyloxyethyl)-N-(1, 3-dioxolan-4-ylmethyl) ammonium and N-(3-acyloxypropyl)-N-(1, 3-dioxolan-4-ylmethyl) ammonium ones.
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More From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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