Studies on the Synthesis of Amino Acids by the Schmidt Reaction. II. New Synthetic Method for ω-Amino Acids and Syntheses of DL-2, 8-Diaminooctanoic Acid and DL-2, 9-Diaminononanoic Acid.

Abstract

A new method was found for synthesis of ω-amino acids in a good yield by the Schmidt reaction, reacting basic acids with calculated amount of hydrazoic acid. In this case, the use of monoalkyl ester of dibasic acid as the starting material gave still better yield. In addition, DL-2, 8-diaminooctanoic acid and DL-2, 9-diaminononanoic acid were obtained in a high yield as their monohydrochlorides from 8-aminooctanoic acid and 9-aminononanoic acid, respectively, which were prepared by the above-mentioned reaction.