Abstract
Trifluoromethylpiperonal was obtained by iodination, demethylation, methylene etherification and trifluoro- methyl reaction of vanillin in a satisfied yield. The chemical structure of the product was identified by 1 H NMR, 13 C NMR, 19 F NMR and HRMS. The optimal reaction conditions were investigated, including trifluoromethylation reagents, solvents, cata- lyst amounts, reaction temperature and reaction time. Meanwhile, three hydroxy substituted derivatives of 3,4-dihydroxy- 5-iodo-benzaldehyde were acquired by trifluoromethylation reaction with this method. Keywords 5-trifluoromethylpiperonal; trifluoromethylation reaction; synthesis
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
