Abstract
Phenolic oxidative coupling of the diphenolic benzylisoquinolines (21) and (22) with potassium ferricyanide afforded the aporphine (3) and the spirocyclohexadienones (23a and b), respectively. The dienones (23a and b) were treated with acid to give two aporphines (4) and (5). Methylation of compounds (3) and (5) with diazomethane gave (±)-thalicsimidine (1).
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