Abstract
1. 1. Mild reduction and alkylation of pentameric nurse shark 19S immunoglobulin molecules to monomeric 7S subunits can be readily accomplished with the formation of one carboxymethylcysteine per heavy chain, i.e. presumably by the cleavage of five disulfide bonds per 19S molecule. 2. 2. Similar treatments of naturally occurring shark 7S immunoglobulin also resulted in the formation of one carboxymethylcysteine per heavy chain. 3. 3. Attempts at reoxidizing mildly reduced shark 7S subunits or 7S molecules into polymers have been unsuccessful. 4. 4. A heretofore undiscovered small and minor component was found associated with the shark 19S molecule. It was suggested that this component may be related to the J chain recently described for mammalian polymeric immunoglobulins.
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