Abstract
Polymeric and monomeric IgM (7S IgM) were obtained from the serum of two patients with Waldenström's macroglobulinemia. The polymeric IgM was used for immunization of rabbits After absorption with unrelated IgM, eight antisera precipitated with the immunizing antigen but did not react with other polymeric IgM proteins The antisera thus disclosed idiotypic antigenic determinants. The precipitate formed between an antiserum and polymeric IgM could be completely inhibited by 7S IgM from the same scrum in double diffusion tests in agarose gels, although only one of the eight antisera precipitated with 7S IgM The reaction of Fabμ and various types of subunits (IgMs) from polymeric IgM with the antisera was also tested The findings arc compatible with the assumption that 7S IgM and polymeric IgM have identical idiotypic antigenic determinants, although the possibility that minor differences exist cannot be excluded.
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