Abstract
1. Urinary excretion of PaA and the increase in the excretion of the vitamin following pantothenate administration were measured in 52 patients with various liver damages. Mutual relations with various liver functions were also studied.2. Both urinary PaA and the increase in excretion following intramuscular administration of the vitamin were reduced in most patients in comparison with those in normal adults.In relatively severe cases, increase in PaA excretion following intramuscular administration of the vitamin was frequently found to be greater than that of normal persons.3. Correlation was found between PaA excretion and various liver functions, especially, TTT, serum cholesterol ester ratio, hippuric acid synthesis and blood pyruvate level.4. The results mentioned above led to the conclusion that a metabolic disturbance of PaA may exist in liver damages leading to the impairment of liver functions, especially, hippuric acid synthesis, and the metabolism of α-keto acid and cholesterol.
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