Abstract
Several differences in the immunological activities of Type I anti-pneumococcal rabbit and horse sera have been reported.1 However, little is known about the difference, if any, in the manner of union between the polysaccharide and its precipitin in the sera of these two animals. In this report, we shall show that such a difference exists. When the immune precipitates were washed with normal saline solution, and the amounts of polysaccharide present in the combined washings were estimated by the method described in the preceding paper, it was found that practically all the polysaccharide in the immune-rabbit precipitate could be accounted for in the washings. On the other hand, no appreciable amount of polysaccharide could be removed from the immune-horse precipitate.Twenty cc. of Type I pneumococcal polysaccharide (0.1 mg. per cc.) were added to 20 cc. of homologous horse or rabbit antiserum. The mixture was incubated at 37°C. for half an hour. The super-nate was poured off and was found to contain an ex...
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