Abstract
ABSTRACT. (1) Cells which are simultaneously infected with both N- and B-tropic murine leukemia virus (MuLV) produce infectious MuLV particles which are sensitive to both N- and B-type Fv-1 restriction. When these dually restricted particles are passaged at low moi, some give rise to N-tropic, and others to B-tropic progeny MuLV. These results indicate that N- and B-tropic MuLVs direct the synthesis of different determinants, and that several of these determinants are incorporated into each particle along with the viral genome. These determinants act as targets for Fv-1 restriction, since the presence of a given determinant in a virion renders the virus sensitive to restriction in cells of the opposite Fv-1 type.
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