Abstract
AbstractThe uptake of administered quinacrine was studied in normal tissues and in Walker. 256 carcinosarcoma tumors implanted in livers and stomachs of rats. Tissue concentrations were measured by a fluorometric technique. The concentration of quinacrine in tumors as compared to that in the liver (T/L ratios) or in the stomach (T/S ratios) was directly related to the size of the tumor. These ratios averaged > 3 in animals with the smallest tumors and < 1 in animals with large tumors. Additional studies comparing uptake of quinacrine and iodoquinacrine suggested that peak T/L ratios occurred at 1 to 3 days with the former compound, with an earlier peak occurring at 1 day with the latter chemical. It is speculated that cancer diagnostic techniques could be developed using tissue measurements, histochemistry, or radioactive scanning of these compounds.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
