Abstract
The submucous plexus of the normal small and large intestine of Calomys callosus was studied by NADH and AChE histochemical techniques and by transmission and scanning electron microscopy. The plexus contains (X +/- SD) 7,488 +/- 293 neurons/cm2 in the duodenum, 5,611 +/- 836 in the jejunum, 2,741 +/- 360 in the ileum, 3,067 +/- 179 in the cecum, and 3,817 +/- 256 in the proximal colon. No ganglia or nerve cell bodies were seen in the esophagus, stomach, distal colon or rectum. The neurons are pear-shaped with a round or oval nucleus and the neuronal cell profile areas were larger in the large intestine than in the small intestine. Most of the neurons display intense AChE activity in the cytoplasm. AChE-positive nerve fibers are present in a primary meshwork of large nerve bundles and in a secondary meshwork of finer nerve bundles. At the ultrastructural level, the ganglia are irregular in shape and covered with fibroblast-like cells. The nucleoplasm of the neurons is finely granular with a few condensations of chromatin attached to the nuclear envelope. In the neuropil numerous varicosities filled with vesicles of different size and electron densities are seen. The pre- and post-synaptic membrane thickenings are asymmetric. Characteristic glial cells with oval nuclei and few organelles are numerous. These data provide a detailed description of this submucosal meshwork.
Highlights
Studies using both light [1,2,3] and scanning electron microscopy [4,5] methods have demonstrated that the submucous plexus consists of a meshwork of connecting nerve strands which extend in various directions, which present ganglia at their junctions
Little information is available about the anatomy of the enteric nervous system of Calomys callosus,a wild rodent with natural resistance to Trypanosoma cruzi infection
We examined the morphology of the myenteric plexus of the digestive tract of Calomys callosus [10] in view of the fact that the different effects of chagasic infection on the enteric plexuses of different species may be due to the structure of the plexuses
Summary
The submucous plexus of the normal small and large intestine of Calomys callosus was studied by NADH and AChE histochemical techniques The plexus acnodntbayintsran(s_xm±issSioDn) and scanning 7,488 ± 293 electron microscopy. neurons/cm in the duodenum, 5,611 ± 836 in the jejunum, 2,741 ± 360 in the ileum, 3,067 ± 179 in the cecum, and 3,817 ± 256 in the proximal colon. The submucous plexus of the normal small and large intestine of Calomys callosus was studied by NADH and AChE histochemical techniques The plexus acnodntbayintsran(s_xm±issSioDn) and scanning 7,488 ± 293 electron microscopy. Neurons/cm in the duodenum, 5,611 ± 836 in the jejunum, 2,741 ± 360 in the ileum, 3,067 ± 179 in the cecum, and 3,817 ± 256 in the proximal colon. No ganglia or nerve cell bodies were seen in the esophagus, stomach, distal colon or rectum. The neurons are pear-shaped with a round or oval nucleus and the neuronal cell profile areas were larger in the large intestine than in the small intestine. Most of the neurons display intense AChE activity in the cytoplasm. Characteristic glial cells with oval nuclei and few organelles are numerous. These data provide a detailed description of this submucosal meshwork
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Schedule a callMore From: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
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