Abstract
Gas chromatography with alkali flame ionization detector (AFID) was applied to the determination of Cinnarizine in plasma. By using AFID, the response of Cinnarizine was about 50-fold greater than that obtained with the hydrogen flame ionization detector (FID). The detection limit of this method was 0.1 ng and the determination limit was 2 ng/ml plasma. The recovery of Cinnarizine in plasma was 104.1±3.4% (n=12). The plasma level in rabbits reached the maximum 1 to 2 hr and biological half-life was 3.8 to 4.6 hr after administration of Cinnarizine capsule formulations. Difference among the pharmaceutical preparations was recognized in the in vitro and in vivo results and it was observed that the dissolution ratio was correlated with the plasma level of Cinnarizine after its oral administration.
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