Abstract
The action of nystatin, a polyene antibiotic, was studied in rat myocardial cells, isolated rat hearts, and intact rats. Myocardial cells responded to 10 and 25 μg nystatin/ml with arrhythmias that could be minimized by elevated concentrations of K + and Mg 2+ or reversed by washing the cells. Similarly, the isolated heart responded to 100 μg nystatin/ml with arrhythmias that could be tempered by addition of elevated concentrations of K + and Mg 2+. The i.v. injection of the drug caused heart failure in intact animals at the 4-mg/kg dose level. At the subcellular level, nystatin made the myocardial cell membranes more rigid, as measured by electron spin resonance spectrometry. These findings indicate a parallel between physiocochemical changes caused by nystatin in the myocardial cell membrane and the biological changes caused by this drug in myocardial cells, isolated heart, and heart of the intact animal.
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