STUDIES ON SCHIZOPHRENIA AND DEPRESSIVE DISEASES BASED ON FUNCTIONAL NEAR-INFRARED SPECTROSCOPY

Abstract

Many investigations have been carried out on functional near infrared spectroscopy (fNIRS) applications in depression and schizophrenia patients that are most mysterious and costliest mental disorders in current society. fNIRS is a new optical method which assesses brain cortex hemodynamic and nervous activities non-invasively and it has been used in medicine as a study tool. Most of the researches of this approach have assessed the homodynamic response of frontal and temporal regions by means of various cognitive tasks. In this research, first, the cognitive task execution techniques have been explained concisely, and then some findings of fNIRS-based researches about depression and schizophrenia have been summarized and assessed. In fNIRS studies that have used various devices with different number of channels, the brain cortex functionality in schizophrenia and depressive patients has been investigated. The results demonstrate that a decrease in prefrontal regions activities can be observed in schizophrenia and depressive patients. Also more detailed studies illustrate ventrolateral, prefrontal and frontopolar region disorders. In severe depressive patients, a decrease in activities of prefrontal and temporal regions has been detected. Therefore, by paying attention to the deficiencies in these regions’ functions, it is possible to treat these diseases.