Abstract
Effects of cortisol administration to adrenalectomized rats on the half-life of RNA in liver, kidney and spleen were examined. The effect of administration of Actinomycin D and cycloheximide was also studied. A significant increase in the half-life of RNA was observed in liver and kidney from cortisol-treated rats but the rate of RNA degradation in spleen was not significantly influenced. Administration of Actinomycin D at a dose which caused 30-50% inhibition of 3H-orotate incorporation into the liver, spleen and kidney also decreased the degradation of labeled RNA in liver and spleen but not in kidney, while cycloheximide, a dose which evoked approximately 40% inhibition of 3H-leucine incorporation into the tissues, exhibited no significant effect on the turnover rate of RNA in all tissues examined.
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