STUDIES ON RAUWOLFIA ALKALOIDS IN DIABETIC HYPERTENSIVE PATIENTS

Abstract

Article1 August 1959STUDIES ON RAUWOLFIA ALKALOIDS IN DIABETIC HYPERTENSIVE PATIENTSALAN S. COHEN, M.D., NORMAN S. STEARNS, M.D., HOWARD LEVITIN, M.D., DAVID HURWITZ, M.D.ALAN S. COHEN, M.D.Search for more papers by this author, NORMAN S. STEARNS, M.D.Search for more papers by this author, HOWARD LEVITIN, M.D.Search for more papers by this author, DAVID HURWITZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-2-238 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRauwolfia serpentina has been reported to have a hypoglycemic effect on both normal and diabetic patients. Neugebauer and Lang1 gave Rauwolfia to 14 normal, three hypertensive and two diabetic patients. In the normal subjects the blood sugar fell an average of 13%, in the others, 11%. These investigators also reported that alloxan diabetic rats could be kept alive by administering Rauwolfia, whereas all untreated controls died in coma within two days. In contrast, Kuschke and Frantz2 described increased blood sugar levels in fasting rabbits after subcutaneous injection of reserpine at various dose levels ranging from 0.1 to 1.0 mg./kg.The...Bibliography1. NeugebauerLang EEK: The effect of total extract of Rauwolfia serpentina benthem on carbohydrate metabolism, Wien. med. Wchnschr. 103: 966, 1955. Google Scholar2. KuschkeFrantz HJJ: Hyperglycemic action of reserpine, Arch. exper. Path. u. Pharmakol. 224: 269, 1955. Google Scholar3. Wilkins RW: Rauwolfia in the treatment of essential hypertension, Am. J. Med. 17: 703, 1954. CrossrefMedlineGoogle Scholar4. Finnerty FA: The value of Rauwolfia serpentina in the hypertensive patient, Am. J. Med. 17: 629, 1954. CrossrefMedlineGoogle Scholar5. LivesayMoyerMiller WRJHSI: Treatment of hypertension with Rauwolfia serpentina alone and combined with other drugs. Results in eighty-four cases, J. A. M. A. 155: 1027, 1954. CrossrefMedlineGoogle Scholar6. Locket S: Oral preparations of Rauwolfia serpentina in treatment of essential hypertension, Brit. M. J. 1: 809, 1955. CrossrefMedlineGoogle Scholar7. McGregorSegel MN: The Rauwolfia alkaloids in the treatment of hypertension, Brit. Heart J. 17: 391, 1955. CrossrefMedlineGoogle Scholar8. Perera GA: Edema and congestive failure related to administration of Rauwolfia serpentina , J. A. M. A. 159: 439, 1955. MedlineGoogle Scholar9. MelickMcGregor RM: Reserpine and extracellular fluid volume, New England J. Med. 256: 1000, 1957. CrossrefMedlineGoogle Scholar10. WallisRoberts WAHV: Statistics, 1956, The Free Press, Glencoe, Illinois. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication November 21, 1958.From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard) Boston City Hospital, Department of Medicine, Harvard Medical School and Diabetes Service, Boston City Hospital.Requests for reprints should be addressed to Alan S. Cohen, M.D., Arthritis Unit, Massachusetts General Hospital, Boston 14, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMethanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan-Induced Diabetic Mice 1 August 1959Volume 51, Issue 2Page: 238-247KeywordsBlood sugarHospital medicineHypertensionMedical servicesOral administrationRabbitsResearch laboratoriesReserpineStatistical dataSubcutaneous injections ePublished: 1 December 2008 Issue Published: 1 August 1959 PDF downloadLoading ...