Abstract
A systematic study of 120 derivatives of quinoline for their bacteriostatic activity against Micrococcus pyogenes var. aureus and Salmonella typhosa and for fungistatic activity against Aspergillus niger has been reported. Thirteen compounds selected from the preliminary screening were further examined for their activity against Micrococcus pyogenes var. aureus, M. pyogenes var. albus, Streptococcus β-hemolyticus, Salmonella typhosa, Salmonella paratyphi A, S. paratyphi B, Shigella dysenteriae, and Escherichia coli. 5-Acetyl-, 5-nitro-, 7-bromo-5-nitro-, 5-formyl-, and 7-bromo-5-formyl- 8-hydroxyquinolines were found to be bacteriostatic at 1 to 5 mcg./cc. against most of the Gram-positive as well as the Gram-negative organisms. High activity of 8-acetoxyquinoline, without a free hydroxyl group and hence nonchelating, is noteworthy. However, the stability of this compound will have to be investigated further.
Published Version
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