Studies on quinoline and isoquinoline derivatives. II. Coupling reaction of haloquinolines and haloisoquinolines with monosubstituted acetylenes in the presence of palladium complex.

Abstract

The quinoline, isoquinoline, and acridine derivatives containing an acetylenic side chain at the pyridine moiety were synthesized by means of coupling reaction of alkyl (or phenyl) acetylenes with the corresponding halogeno derivatives in the presence of a palladium triphenylphosphine complex.