STUDIES ON PATHOLOGICAL FACTORS AND BLOOD VESSEL INVASION BY USING IMMUNOPERIOXIDASE TECHNIQUE FOR FACTOR VIII RELATED ANTIGEN IN BREAST CANCER (2ND REPORT)

Abstract

One hundred and thirty six patients with primary breast cancer were microscopically examinded for studying the blood vessel invasion (BVI) by using factor VIII related antigen (FVIIIRAg) staining and the relations of BVI to tumor size, stage, infiltrative growth (INF), histological extension of tumor, cell grade and 5-year survival rate were studied. When the main lesions were stained with FVIIRAg, BVI was found in 33.8% of the subjects. The 5-year survival rate was significantly reduced in the cases with BVI demonstrated by FVIIIRAg staining, Frequencies of BVI in T3 and stage III were as significantly high as 50.0% and 43.6% respectively. The 5-year survival rate in stage III cases with BVI was significantly better than without BVI. In γ or α state of infiltrate growth the frequency of BVI was 42.9% or 19.0% respectively and in γ state of INF the frequency of BVI was significantly higher than that in α state. As to the histological extension of tumor, the frequency of BVI in group s, p+s was 51.9% and the prognosis tended to be poorer. The highest-cell grade tumors had the highest frequency of BVI (42.9%), and BVI might indicate poor prognosis. Studying BVI by means of FVIIIRAg staining appears available for estimating the prognosis of breast cancer.